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KMID : 0380620160480060574
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Korean Journal of Food Science and Technology
2016 Volume.48 No. 6 p.574 ~ p.581
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Antioxidant activities, production of reactive oxygen species, and cytotoxic properties of fractions from aerial parts of glasswort (Salicornia herbacea L.)
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Kang S-Mee
Hong Jung-Il
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Abstract
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Glasswort (Salicornia herbacea L.) is an edible halophyte that grows in salt marshes. In the present study, antiand pro-oxidant activities and cytotoxic properties of glasswort were investigated. Solvent fractions, including fractions of hexane, ethylether (Fr.E), ethylacetate (Fr.EA), butanol and water, were prepared from a 70% methanol extract of glasswort aerial parts. Fr.EA contained the highest levels of total polyphenols and flavonoids, showing the strongest scavenging activities against DPPH and ABTS radicals, and nitrite. In addition Fr.EA showed the most potent cytotoxic effects on HCT-116 colon cancer cells and INT-407 normal intestinal cells, followed by Fr.E. Most fractions also decreased the level of reactive oxygen species in the treated cells, but generated H2O2 in the medium. The cytotoxic activity of Fr.EA was more pronounced in the presence of ascorbic acid or N-acetylcysteine. These results indicate that the fractions from aerial parts of glasswort exhibit both anti- and pro-oxidant activities, and these activities modulate cytotoxic properties.
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KEYWORD
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glasswort, antioxidant, reactive oxygen species, pro-oxidant, cytotoxicity
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